Publications

Preprints

Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites
Nelson AD, Catalfio AM, Gupta JM, Min L, Caballero-Floran RN, Dean KP, Elvira CC, Derderian KD, Kyoung H, Sahagun A, Sanders SJ, Bender KJ, Jenkins PM.
bioRxiv. 2022

 

CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder
Serena Tamura, Andrew D. Nelson, Perry W.E. Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, Congyi Lu, Elizabeth C. Hamada, Roy Ben-Shalom, Jen Q. Pan, Jeanne T. PazStephan J. SandersNavneet Matharu, Nadav AhituvKevin J. Bender
bioRxiv. 2022

 

Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice
Jonathan S Schor, Isabelle Gonzalez Montalvo, Perry W E Spratt, Rea J Brakaj, Jasmine A Stansil, Kevin J Bender, Alexandra B Nelson
bioRxiv. 2021

 

Inferring neuronal ionic conductances from membrane potentials using CNNs.
Ben-Shalom R, Balewski J, Siththaranjan A, Baratham V, Kyoung  H, Kim KG, Bender KJ, Bouchard KE.
bioRxiv. 2019

Peer reviewed manuscripts

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Fazel Darbandi S, Nelson AD, Ling-lin Pai E, Bender KJ, Ruberstein JLR.
J Neurodevelopmental Disorders. 2022 Feb 5

 

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.
Echevarria-Cooper DM, Hawkins NA, Misra SN, Huffman A, Thaxton T, Thompson CH, Ben-Shalom R, Nelson AD, Lipkin AM, George Jr. AL, Bender KJ, Kearney JA
Human Molecular Genetics. 2022 Apr 13

 

NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.
Ben-Shalom R, Artherya NS, Ladd A, Cross C, Sanghevi H, Kim KG, Korngreen A, Bouchard KE, Bender KJ.  
J Neurosci Methods, 2021 Oct 30

 

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex.
Liang L, Darbandi SF, Pochareddy S, Gulden FO, Gilson MC, Sheppard BK, Sahagun A, An J, Werling DM, Rubenstein JL, Šestan N, Bender KJ, Sanders SJ.
Genome Medicine. 2021 Aug 21; 13(135);

 

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells.
Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Keeshen CM, Sander SJ, Bender KJ.
Cell Reports. 2021 Aug 3; 36(5);

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Functional microstructure of CaV-mediated calcium signaling in the axon initial segment.
Lipkin AM, Cunniff MM, Spratt PWE, Lemke SM, Bender KJ.

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.
Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL.
Neuron. 2020 Aug 5;107(3):454-469.

 

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants.
Thompson CH, Ben-Shalom R, Bender KJ, George AL.
Journal of General Physiology. 2020 Mar 2;152(3):e201912442.

 

 

Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.
Burke KJ Jr, Keeshen CM, Bender KJ.
Neuron. 2018 Sep 5;99(5):969-984.

 

The CaMKII/NMDA receptor complex controls hippocampal
synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.
Nature Communications. 2018 May 25;9(1):2069.

 

Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ.
Elife. 2017 Dec 5;6. pii: e31991. doi: 10.7554/eLife.31991.

 

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.
Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ.
Cell Reports 2017 Jul 5;20(1):21-29.

 

D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.
Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ.
Journal of Neuroscience. 2017 Jun 14;37(24):5846-5860.

 

A Visible-Light-Sensitive Caged Serotonin.
Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R.
ACS Chemical Neuroscience. 2017 May 17;8(5):1036-1042.

 

Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.
Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ.
Biological Psychiatry. 2017 Aug 1;82(3):224-232.

 

 

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.
Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ.
Cell Reports. 2016 Aug 9;16(6):1518-26.

 

 

Medial amygdalar aromatase neurons regulate aggression in both sexes.
Unger EK, Burke KJ Jr, Yang CF, Bender KJ, Fuller PM, Shah NM.
Cell Reports. 2015 Feb 3;10(4):453-62.

 

Interlamellar CA1 network in the hippocampus.
Yang S, Yang S, Moreira T, Hoffman G, Carlson GC, Bender KJ, Alger BE, Tang CM.
PNAS. 2014 Sep 2;111(35):12919-24.

 

Reviews

Dendritic Integration Dysfunction in Neurodevelopmental Disorders.
Nelson AD, Bender KJ.   
Developmental Neuroscience. June 17, 2021

 

Modulation of Ion Channels in the Axon: Mechanisms and Function.
Burke KJ Jr, Bender KJ.   
Frontiers in Cellular Neuroscience. 2019 May 17;13:221.

 

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.
Cell. 2018 Jul 26;174(3):505-520.

 

Progress in Understanding and Treating SCN2A-Mediated Disorders.
Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.
Trends in Neuroscience. 2018 Apr 22. pii: S0166-2236(18)30072-9.

 

Short- and long-term plasticity at the axon initial segment.
Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ.
Journal of Neuroscience. 2011 Nov 9;31(45):16049-55.

 

The physiology of the axon initial segment.
Bender KJ, Trussell LO.
Annual Reviews in Neuroscience. 2012;35:249-65.

 

Synaptic plasticity in inhibitory neurons of the auditory brainstem.
Bender KJ, Trussell LO.
Neuropharmacology. 2011 Apr;60(5):774-9.

 

Previews