Publications

Preprints

Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity.
Alexander RPD, Bender KJ.
bioRxiv. 2019

CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder
Serena Tamura, Andrew D. Nelson, Perry W.E. Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, Congyi Lu, Elizabeth C. Hamada, Roy Ben-Shalom, Jen Q. Pan, Jeanne T. Paz, Stephan J. Sanders, Navneet Matharu, Nadav Ahituv, Kevin J. Bender
bioRxiv. 2022

 

Inferring neuronal ionic conductances from membrane potentials using CNNs.
Ben-Shalom R, Balewski J, Siththaranjan A, Baratham V, Kyoung  H, Kim KG, Bender KJ, Bouchard KE.
bioRxiv. 2019

Peer reviewed manuscripts

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD
Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ.
Neuron 2024

Preview by Romana Hyde and Stephanie Rudolph
News coverage from NIMH
 

 

Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites
Nelson AD, Catalfio AM, Gupta JM, Min L, Caballero-Floran RN, Dean KP, Elvira CC, Derderian KD, Kyoung H, Sahagun A, Sanders SJ, Bender KJ, Jenkins PM.
Neuron 2024

Transmitter News Coverage

Dynamic foraging behavior performance is not affected by Scn2a haploinsufficiency
Schamiloglu S,  Zhou M, Kwan AC, Bender KJ.
eNeuro. 2023

 

 

Axon initial segment GABA inhibits action potential generation throughout periadolescent development
Lipkin AM, Bender KJ.
J Neurosci. 2023

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance
Schamiloglu S, Lewis E, Hergarden AC, Bender KJ, Whistler JL
Biologial Psyciatry. 2023
Priority Communication

Preview by Monserrat Avila-Zozaya

Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice
Ehrlich, AT, Couvineau P, Schamiloglu S, Wojcik S, Da Fonte D, Mezni A, von Zastrow M, Bender KJ, Bouvier M, Kieffer BL
Frontiers in Cellular Neuroscience. 2022

 

Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice
Schor JS, Montalvo IG, Spratt PWE, Brakaj RJ, Stansil JA, Bender KJ, Nelson AB
eLife. 2022 July 4

 

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Fazel Darbandi S, Nelson AD, Ling-lin Pai E, Bender KJ, Ruberstein JLR.
J Neurodevelopmental Disorders. 2022 Feb 5

 

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.
Echevarria-Cooper DM, Hawkins NA, Misra SN, Huffman A, Thaxton T, Thompson CH, Ben-Shalom R, Nelson AD, Lipkin AM, George Jr. AL, Bender KJ, Kearney JA
Human Molecular Genetics. 2022 Apr 13

 

NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.
Ben-Shalom R, Artherya NS, Ladd A, Cross C, Sanghevi H, Kim KG, Korngreen A, Bouchard KE, Bender KJ.  
J Neurosci Methods, 2021 Oct 30

 

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex.
Liang L, Darbandi SF, Pochareddy S, Gulden FO, Gilson MC, Sheppard BK, Sahagun A, An J, Werling DM, Rubenstein JL, Šestan N, Bender KJ, Sanders SJ.
Genome Medicine. 2021 Aug 21; 13(135);

 

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells.
Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Keeshen CM, Sander SJ, Bender KJ.
Cell Reports. 2021 Aug 3; 36(5);
Preview by Leonard Kazmarek
Spectrum News coverage

 

 

 

Functional microstructure of CaV-mediated calcium signaling in the axon initial segment.
Lipkin AM, Cunniff MM, Spratt PWE, Lemke SM, Bender KJ.
Journal of Neuroscience. 28 April 2021, 41 (17) 3764-3776

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.
Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL.
Neuron. 2020 Aug 5;107(3):454-469.

 

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants.
Thompson CH, Ben-Shalom R, Bender KJ, George AL.
Journal of General Physiology. 2020 Mar 2;152(3):e201912442.

 

 

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex.
Spratt PWE, Ben-Shalom R, Keeshen CM, Burke KJ Jr, Clarkson RL, Sanders SJ, Bender KJ.
Neuron. 2019 Aug 21;103(4):673-685.
Preview by Leonard Kaczmarek
F1000 Recommendation by Holger Lerche and Yuanyuan Liu

 

 

 

Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.
Burke KJ Jr, Keeshen CM, Bender KJ.
Neuron. 2018 Sep 5;99(5):969-984.

 

The CaMKII/NMDA receptor complex controls hippocampal
synaptic transmission by kinase-dependent and independent mechanisms.
Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.
Nature Communications. 2018 May 25;9(1):2069.

 

Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ.
Elife. 2017 Dec 5;6. pii: e31991. doi: 10.7554/eLife.31991.

 

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.
Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ.
Cell Reports 2017 Jul 5;20(1):21-29.

 

D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.
Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ.
Journal of Neuroscience. 2017 Jun 14;37(24):5846-5860.

 

A Visible-Light-Sensitive Caged Serotonin.
Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R.
ACS Chemical Neuroscience. 2017 May 17;8(5):1036-1042.

 

Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.
Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ.
Biological Psychiatry. 2017 Aug 1;82(3):224-232.

 

 

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.
Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ.
Cell Reports. 2016 Aug 9;16(6):1518-26.

 

 

Medial amygdalar aromatase neurons regulate aggression in both sexes.
Unger EK, Burke KJ Jr, Yang CF, Bender KJ, Fuller PM, Shah NM.
Cell Reports. 2015 Feb 3;10(4):453-62.

 

Interlamellar CA1 network in the hippocampus.
Yang S, Yang S, Moreira T, Hoffman G, Carlson GC, Bender KJ, Alger BE, Tang CM.
PNAS. 2014 Sep 2;111(35):12919-24.

 

Reviews

SCN2A-Related Disorders
Abbott M, Bender KJ, Brunklaus A, Damarest S, Egan S, Haviland I, Kearney JA, Myers LS, Olson HE, Sanders SJ, SanInocencio C, Symonds J, Thompson CH.   
Cambridge Elements. 2024

 

Dendritic Integration Dysfunction in Neurodevelopmental Disorders.
Nelson AD, Bender KJ.   
Developmental Neuroscience. June 17, 2021

 

Modulation of Ion Channels in the Axon: Mechanisms and Function.
Burke KJ Jr, Bender KJ.   
Frontiers in Cellular Neuroscience. 2019 May 17;13:221.

 

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.
Cell. 2018 Jul 26;174(3):505-520.

 

Progress in Understanding and Treating SCN2A-Mediated Disorders.
Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.
Trends in Neuroscience. 2018 Apr 22. pii: S0166-2236(18)30072-9.

 

Short- and long-term plasticity at the axon initial segment.
Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ.
Journal of Neuroscience. 2011 Nov 9;31(45):16049-55.

 

The physiology of the axon initial segment.
Bender KJ, Trussell LO.
Annual Reviews in Neuroscience. 2012;35:249-65.

 

Synaptic plasticity in inhibitory neurons of the auditory brainstem.
Bender KJ, Trussell LO.
Neuropharmacology. 2011 Apr;60(5):774-9.

 

Previews

Flipping the Switch: Homeostatic Tuning of Chandelier Synapses Follows Developmental Changes in GABA Polarity.
Lipkin AM, Bender KJ.
Neuron. 2020 Apr 22;106(2):199-201.