Preprint on CRISPRa approach to rescue SCN2A haploinsufficiency posted

April 15, 2022
Autism-associated variants in the gene SCN2A commonly impair gene function. This leads to haploinsufficiency, where a single functional copy cannot compensate for the loss of its partner. Here, Serena Tamura, a recently-graduated student in the Ahituv lab at UCSF, worked with us to test whether...

Andrew is awarded a fellowship from NIMH!

July 22, 2021
Congratulations to Dr. Andrew Nelson, who just received word that his F32 has been awarded!  Andrew is studying potential points of convergence across genes implicated in neurodevelopmental disorders.

Anna's paper published in J Neurosci!

April 28, 2021
A detailed understanding of AP-evoked calcium entry in the axon initial segment of prefrontal pyramidal cells. Several interesting takeaways: 1) There are far more channel types in these cells than others we've examined in the past. Cartwheel cells have only 2 types of CaVs in their initial...

New Preprint from Perry Spratt on SCN2A

February 17, 2021
Perry has examined what happens to pyramidal cells when SCN2A expression is completely knocked out. Oddly, despite losing the entirety of NaV1.2 conductance, the cells are more excitable than normal. Read here as we made an effort to figure out why: Paradoxical hyperexcitability from NaV1.2 sodium...

New Preprint from Anna Lipkin on AIS calcium

December 02, 2020
Anna explored the intricacies of action potential-evoked calcium signals in prefrontal pyramidal cells and found that there is a rather complicated and interesting arrangement of different channel types that give rise to different calcium signals through this ever-so-important neuronal structure....

Chenyu Wang receives an Action Potential Grant from the FamilieSCN2A Foundation

August 31, 2020
Chenyu is one of two awardees of a grant from the FamilieSCN2A Foundation, which supports research into the effects of SCN2A Disorders on brain function. Chenyu's thesis work is focused on the role of SCN2A in cerebellar processing. As you can tell, he is quite excited.      

Perry Spratt (virtually) defends his thesis. Congrats Perry!

August 31, 2020
What better way to defend during a pandemic than to have the support of floating avocados.  

Henry Kyoung joins the lab as a research associate.

August 30, 2020
We continue our forum with the Nelson Lab via Zoom to actively address issues of implicit biases in science and reemphasize our own commitment and responsibility in promoting diversity, equity, and inclusion in academic research.