New Preprint from Perry Spratt on SCN2A

Perry has examined what happens to pyramidal cells when SCN2A expression is completely knocked out. Oddly, despite losing the entirety of NaV1.2 conductance, the cells are more excitable than normal. Read here as we made an effort to figure out why:

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells