Publications

Inferring neuronal ionic conductances from membrane potentials using CNNs.
Ben-Shalom R, Balewski J, Siththaranjan A, Baratham V, Kyoung  H, Kim KG, Bender KJ, Bouchard KE.

bioRxiv. 2019

Intrinsic dendritic integration features of prefrontal layer 5 pyramidal cell subclasses

Selin Schamiloglu, Rebecca L. Clarkson, Natalia S. Stone, Alayna T. Liptak, Kevin J. Bender

Journal of Neuroscience, 2025

CRISPR activation for SCN2A-related neurodevelopmental disorders

Serena Tamura, Andrew D. Nelson, Perry W. E. Spratt, Elizabeth C. Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, Congyi Lu, Roy Ben-Shalom, Sunrae E. Taloma, Selin Schamiloglu, Ying C. Li, Lia Min, Paul M. Jenkins, Jen Q. Pan, Jeanne T. Paz, Stephan J. Sanders, Navneet Matharu, Nadav Ahituv & Kevin J. Bender

Nature, 2025

Coverage in the Transmitter

Coverage in UCSF News!

Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

Alexander R, Bender K.

Cell Reports, 2025

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

Barron J, Mroz N, Taloma S, Dahlgren M, Ortiz-Carpena J, Keefe M, Escoubas C, Dorman L, Vainchtein I, Chiaranunt P, Kotas M, Nowakowski T, Bender K, Molofsky A, Molofsky A.

Science, 2024

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ.

Neuron, 2024

Preview by Romana Hyde and Stephanie Rudolph

News coverage from NIMH

Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites

Nelson AD, Catalfio AM, Gupta JM, Min L, Caballero-Floran RN, Dean KP, Elvira CC, Derderian KD, Kyoung H, Sahagun A, Sanders SJ, Bender KJ, Jenkins PM.

Neuron, 2024

Transmitter News Coverage

Dynamic foraging behavior performance is not affected by Scn2a haploinsufficiency

Schamiloglu S,  Zhou M, Kwan AC, Bender KJ.

eNeuro, 2023

Axon initial segment GABA inhibits action potential generation throughout periadolescent development

Lipkin AM, Bender KJ.

J Neuroscience, 2023

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Schamiloglu S, Lewis E, Hergarden AC, Bender KJ, Whistler JL

Biological Psychiatry, 2023 - Priority Communication

Preview by Monserrat Avila-Zozaya

Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice

Ehrlich, AT, Couvineau P, Schamiloglu S, Wojcik S, Da Fonte D, Mezni A, von Zastrow M, Bender KJ, Bouvier M, Kieffer BL

Frontiers in Cellular Neuroscience, 2022

Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice

Schor JS, MontalvoIG, Spratt PWE, Brakaj RJ, Stansil JA, Bender KJ, Nelson AB

eLife, 2022

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.

Fazel Darbandi S, Nelson AD, Ling-lin Pai E, Bender KJ, Ruberstein JLR.

Journal of Neurodevelopmental Disorders, 2022

Cellular and behavioral effects of altered Na_V1.2 sodium channel ion permeability in Scn2a^K1422E mice.

Echevarria-Cooper DM, Hawkins NA, Misra SN, Huffman A, Thaxton T, Thompson CH, Ben-Shalom R, Nelson AD, Lipkin AM, George Jr. AL, Bender KJ, Kearney JA

Human Molecular Genetics, 2022

NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.

Ben-Shalom R, Athreya NS, Ladd A, Cross C, Sanghvi H, Kim KG, Korngreen A, Bouchard KE, Bender KJ.  

Journal of Neuroscience Methods, 2021

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex.

Liang L, Darbandi SF, Pochareddy S, Gulden FO, Gilson MC, Sheppard BK, Sahagun A, An J, Werling DM, Rubenstein JL, Šestan N, Bender KJ, Sanders SJ.

Genome Medicine, 2021

Paradoxical hyperexcitability from Na_V1.2 sodium channel loss in neocortical pyramidal cells.

Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Keeshen CM, Sander SJ, Bender KJ.

Cell Reports, 2021

Preview by Leonard Kazmarek
Spectrum News coverage

Functional microstructure of CaV-mediated calcium signaling in the axon initial segment.

Lipkin AM, Cunniff MM, Spratt PWE, Lemke SM, Bender KJ.

Journal of Neuroscience, 2021

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.

Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL.

Neuron, 2020

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants.

Thompson CH, Ben-Shalom R, Bender KJ, George AL.

Journal of General Physiology, 2020

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex.

Spratt PWE, Ben-Shalom R, Keeshen CM, Burke KJ Jr, Clarkson RL, Sanders SJ, Bender KJ.

Neuron, 2019

Preview by Leonard Kaczmarek
F1000 Recommendation by Holger Lerche and Yuanyuan Liu

Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.

Burke KJ Jr, Keeshen CM, Bender KJ.

Neuron, 2018

The CaMKII/NMDA receptor complex controls hippocampal
synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.

Nature Communications, 2018

Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.

Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ.

eLife, 2017

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.

Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ.

Cell Reports, 2017

D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.

Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ.

Journal of Neuroscience, 2017

A Visible-Light-Sensitive Caged Serotonin.

Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R.

ACS Chemical Neuroscience, 2017

Opposing Effects on Na_V1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.

Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ.

Biological Psychiatry, 2017

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.

Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ.

Cell Reports, 2016

Medial amygdalar aromatase neurons regulate aggression in both sexes.

Unger EK, Burke KJ Jr, Yang CF, Bender KJ, Fuller PM, Shah NM.

Cell Reports, 2015

Interlamellar CA1 network in the hippocampus.

Yang S, Yang S, Moreira T, Hoffman G, Carlson GC, Bender KJ, Alger BE, Tang CM.

PNAS, 2014

SCN2A-Related Disorders

Abbott M, Bender KJ, Brunklaus A, Damarest S, Egan S, Haviland I, Kearney JA, Myers LS, Olson HE, Sanders SJ, SanInocencio C, Symonds J, Thompson CH.   

Cambridge Elements, 2024

Dendritic Integration Dysfunction in Neurodevelopmental Disorders.

Nelson AD, Bender KJ.   

Developmental Neuroscience, 2021

Modulation of Ion Channels in the Axon: Mechanisms and Function.

Burke KJ Jr, Bender KJ.      

Frontiers in Cellular Neuroscience, 2019

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. 

Cell, 2018

Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends in Neuroscience, 2018

Short- and long-term plasticity at the axon initial segment.

Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ.

Journal of Neuroscience, 2011

The physiology of the axon initial segment.

Bender KJ, Trussell LO.

Annual Reviews in Neuroscience, 2012

Synaptic plasticity in inhibitory neurons of the auditory brainstem.

Bender KJ, Trussell LO.

Neuropharmacology, 2011

Flipping the Switch: Homeostatic Tuning of Chandelier Synapses Follows Developmental Changes in GABA Polarity.

Lipkin AM, Bender KJ.

Neuron, 2020